Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation
Description
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The antiretroviral drugs, saquinavir (SQV) and darunavir (DRV), inhibit oligodendrocyte maturation through decreasing the acidity of endolysosomes. This SQV- and DRV-driven inhibition can be rescued by MLSA1, a TRPML agonist, by regulating the endolysosomal pH during oligodendrocyte differentiation.
Acknowledgements
References
Festa, L., Roth, L. M., Jensen, B. K., Geiger, J. D., Jordan-Sciutto, K. L., & Grinspan, J. B. (2021). Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation: Implications for Lysosomal Stress. Journal of Neuroimmune Pharmacology, 16(1), 169–180. https://doi.org/10.1007/s11481-019-09893-8
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