PROTAC: Proteolytic Targeting Chimera

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. PROTAC is a progressing technology with a huge scope in protein degradation based therapies for cancer and Alzheimer's like disease. It is a small molecule which has two active domains and a linker. One of the domain binds to the target protein while other one binds to the E3 ligase enzyme, bringing the two proteins in close proximity of each other causing ubiquitination of target protein, followed by its proteasomal degradation. This can allow us to selectively eliminate target proteins.

Acknowledgements

References

Kathleen M Sakamoto. (2010) Protacs for Treatment of Cancer. Pediatric research. https://www.nature.com/articles/pr201091?proof=true Philip P. Chamberlain. (2019) Development of targeted protein degradation therapeutics. Nature chemical biology. https://www.nature.com/articles/s41589-019-0362-y

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