PROTAC - mediated modulation of the immune response against cancer cells.
Description
Tumor cell killing is selectively carried out by T cells, which recognize T cell receptor (TCR) antigens produced from PROTAC-induced proteolysis. The cell surface displays new MHC-I peptides derived from cancer cell-specific antigens via PROTAC-induced protein degradation. PROTACs specifically target proteins expressed in cancer settings, resulting in the generation of unique MHC-I complexes. These complexes can be recognized by TCRs on T cells.
Acknowledgements
References
Kamaraj, Rajamanikkam, et al. "Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions." Bioconjugate Chemistry (2024).
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