PROTAC controlled CAR-T cell therapy
Description
Model illustrating the control of CAR T cell activity through CAR degradation. A novel CAR T cell safety strategy specifically targets the CAR protein rather than the CAR T cell itself. The PROTAC compound, directed against the bromodomain (BD), degrades the BD-containing CAR protein. Notably, CAR expression is restored upon removal of the PROTAC compound from the cell or system, demonstrating its reversibility.
Acknowledgements
References
Lee, So Myoung, et al. "A chemical switch system to modulate chimeric antigen receptor T cell activity through proteolysis-targeting chimaera technology." ACS Synthetic Biology 9.5 (2020): 987-992.
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