Progression of Parkinson's Disease in the Substantia Nigra
Description
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Parkinson's Disease is a complex, progressive neurodegenerative disease involving loss of dopaminergic neurons and Lewy bodies, which are aggregations of alpha synuclein protein clusters bound to ubiquitin. While the mechanism is not fully understood, Lewy bodies are thought to damage dopaminergic neurons when they form in the substantia nigra and interfere with pathways responsible for motor function and other cognitive processes.
Acknowledgements
References
National Institute of Neurological Disorders and Stroke National Institutes of Health. (2020) Parkinson's Disease Hope Through Research. NIH. https://www.ninds.nih.gov/sites/default/files/parkinsons_htr_english_20-ns-139_508c.pdf
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