Production of Lipid Nanoparticles by High-Pressure Homogenization
Description
The high-pressure homogenization (HPH) method is a standard procedure for preparing lipid nanoparticles. This method generally involves three steps:
I. dispersion of the lipid phase in an aqueous solution containing surfactants,
II. particle size reduction and obtaining the coarse emulsion by high-speed mixing, and
III. homogenization under high pressure to achieve the required particle size and size distribution.
Acknowledgements
Sally Kim
References
Tapeinos, C., Battaglini, M., & Ciofani, G. (2017). Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. Journal of Controlled Release, 264, 306-332.
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