Probable mechanism of SFTSV pathogenesis.
Description
SFTSV transmission to humans commonly occurs from virus-carrying tick-bites. The SFTSV then invades the lymph node nearest to the tick-bite wound, targeting B-cells, and impairing host immune response from invading pathogen. As the virus goes to the systemic circulation, immune cells are over-stimulated causing cytokine storm and SIRS. Thrombocytopenia is a hallmark of SFTSV infection, several mechanisms may be attributed to the decrease of platelet count.
Acknowledgements
References
Casel, M.A., Park, S.J. & Choi, Y.K. Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy. Exp Mol Med 53, 713–722 (2021).
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