Pre-Eclampsia Prevents Mother-to-Child HIV Transmission
Description
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Placental anti-histone 2A (H2A) staining reveals a protective role of pre-eclampsia on mother-to-child transmission of HIV. In normotensive placentae, H2A+ (receptor-expressing) syncytiotrophoblasts (STB) allow the transmission of HIV from the maternal to fetal circulation. The pathologies linked to pre-eclampsia such as syncytial bridges (SB) promote the localization of H2A- (receptor-less) STB on the periphery, forming a barrier against mother-to-child transmission of HIV.
Acknowledgements
References
Moodley, M., Moodley, J., Naicker, T. Evaluation of placental chorionic villi histone 2A expression in HIV-infected women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 245:127-133 (2020). 10.1016/j.ejogrb.2019.12.025
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