Positive feedback loop mechanism between oxidative stress and NF-κB activation
Description
In the absence of stimulation, NF-κB is bound in the cytoplasm by the inhibitory protein IκBα. In monocytes and microglial cell lines, IκBα is degraded when cells are stimulated by, for example, lipopolysaccharide (LPS , LPS) or interferon γ (Interferon γ,IFN γ), releasing subunits of NF-κB, such as p65/RelA, which allow it to enter the nucleus and activate the expression of downstream genes, such as NOX2, and in the case of NOX2 expression is inhibited in cells overexpressing IκBα.
Acknowledgements
References
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