Platelet induce metastasis via transfer of 12-lipoxygenase
Description
The interaction of platelets and cancer cells induces the release of microparticles containing 12-lipoxygenase, which is transferred to the cancer cells that generate 12-HETE. 12-HETE is then esterified to membrane phospholipids, and this phenomenon is associated with the acquisition of epithelial-mesenchymal transitions and migratory properties leading to metastasis.
Acknowledgements
References
Contursi et al. J Lipid Res. 2021:62:100109. doi: 10.1016/j.jlr.2021.100109. Epub 2021 Aug 21
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