PKR Mechanism of Action
Description
Protein kinase R (PKR) is a component of cell innate immunity against viruses that contain or produce double-stranded RNA (dsRNA). When such a virus (for example, a rotavirus) invades a cell, its dsRNA binds the PKR and makes it dimerise. The dimerised PKR acquires the kinase activity and phosphorylates the alpha subunit of eIF2, which, in turn, stops translation in the cell.
Acknowledgements
The translation complex was used from the "Protein Translation Cascade" template by Valeria Yartseva
References
Jacquet, S., Culbertson, M., Zhang, C., El Filali, A., De La Myre Mory, C., Pons, J. B., ... & Etienne, L. (2022). Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions. Science Advances, 8(47), eadd7540.
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
.gif)
