PKM2-Specific siRNA induces Apoptosis and Tumor Regression
Description
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PKM2 expression levels play an important role in glycolysis and hence, tumor growth as cancer cells modify normal cell metabolism for their own proliferation. In this study, the authors used PMK2 specific siRNA to knockdown PKM2 and examine its effect on cell proliferation, apoptosis and tumor growth. The results show that si156 decreased tumor cell viability, increased tumor cell apoptosis and decreased xenograft tumor volume without affecting normal non-cancerous cell viability.
Acknowledgements
References
Goldberg, MS. et. al. (2012) Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression.. The Journal of Experimental Medicine. https://www.ncbi.nlm.nih.gov/pubmed/22271574; Christofk, HR. et. al. (2008) Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. https://www.nature.com/articles/nature06667
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