Pharmacokinetics of Paracetamol

Description

Paracetamol is a painkiller and exerts its analgesic effects by prostaglandin inhibition. Following absorption from the Gastrointestinal tract, paracetamol is metabolised predominantly in the liver where it is conjugated into inactive glucuronide and sulphate conjugates, which are excreted in urine, and toxic N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione. Following detoxification of NAPQI, the cysteine and mercapturic acid conjugates produced are excreted.

Acknowledgements

S P Ramya Ranjan Nayak (Peer reviewer)

References

Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar-Apr;7(2):93-107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.

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