Personalized Cell Therapies to Combat COVID-19

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. This figure outlines a strategy to generate personalized viral-specific T cells as a potential therapeutic to prevent and/or treat SARS-CoV-2 infections among vulnerable populations, such as cancer patients. An individual's own monocytic-DCs are pulsed with SARS-CoV-2 peptides and then used to prime that same individual's T cells in order to generate SARS-CoV-2-specific T cells. These T cells may be cryopreserved or infused into the vulnerable individual as prophylaxis or treatment against COVID-19.

Acknowledgements

References

Keller, MD et. al. (2020) Virus-specific T-cell therapies for patients with primary immune deficiency. Blood. Chernykh, E, et. al. (2019) Immunotherapy with interferon-alpha-induced dendritic cells for chronic HCV infection (the results of pilot clinical trial). Immunologic research. Ko, EJ, et. al. (2019) Dendritic Cells in HIV/SIV Prophylactic and Therapeutic Vaccination. Viruses. Ahmed SF, et. al. (2020) Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies. Viruses.

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