Perineuronal net composition
Description
Perineuronal nets (PNNs) consist of a backbone of hyaluronan to which different chondroitin sulfate proteoglycans (CSPGs) bind. CSPGs consist of a core protein and a chondroitin sulfate glycosaminoglycan (CS-GAG) chains. The CSPGs-hyaluronan bindings are stabilized by linking proteins. The extracellular matrix glycoprotein tenascin- R further links the CSPGs to each other. They form a structural brake to limit synaptic plasticity and capture molecules like Semaphorin 3A and OTX2.
Acknowledgements
References
Fawcett, J.W., et al. (2019) The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function. Nat Rev Neurosci 20, 451–465
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