Pathophysiology of leptin gene and leptin receptor mutation in obesity
Description
A flowchart of how leptin gene and leptin receptor mutation leads to obesity.
Acknowledgements
References
Chaves, C., Kay, T., & Anselmo, J. (2022). Early onset obesity due to a mutation in the human leptin receptor gene. Endocrinology, diabetes & metabolism case reports, 2022, 21-0124. Advance online publication. https://doi.org/10.1530/EDM-21-0124
Dubern B, Clement K. (2012) Leptin and Leptin receptor-related Monogenic obesity. Doi: https://doi.org/10.1016/j.biochi.2012.05.010
Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart A. J., Gojobori T, Isenovic E. R. (2021) Leptin and Obesity: Role and Clinical Implication. Doi: https://doi.org/10.3389/fendo.2021.585887
Lister, N.B., Baur, L.A., Felix, J.F. et al. Child and adolescent obesity. Nat Rev Dis Primers 9, 24 (2023). https://doi.org/10.1038/s41572-023-00435-4
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