Oxidative burst in phagocytes
Description
ROS have a host defence role against invading microbes by generating NOX enzymes. NADPH oxidase generates ROS in neutrophils or macrophages. The pathogen is engulfed in the phagolysosome and NADPH is triggered to generate superoxide (O2•− ). Superoxide dismutase (SOD) converts O2•− to Hydrogen Peroxide (H₂O₂). Myeloperoxidase (MPO) converts H₂O₂ to HOCl, which is a toxic compound that kills pathogens such as fungi.
Acknowledgements
References
Reprinted from (Dahlgren & Karlsson, 1999).
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