Overview of Strategies to Make Migratory Stem Cells Therapeutic Against Cancer

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Stem cells (SCs) migrate to tumors by following chemokine gradients and can be engineered with anti-tumor properties, including 1) producing cytotoxic proteins or carrying enzymes that convert a prodrug to cytotoxic products, 2) secreting chemokines to activate immune cells against the tumor, 3) producing oncolytic viruses, 4) carrying chemotherapeutics encapsulated in nanoparticles, or 5) conjugation to a carrier of immunotherapies to prevent the downregulation of T-cells.

Acknowledgements

References

M. R. Loebinger. (2009) Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699841/pdf/ukmss-4545.pdf C. Song. (2011) Thymidine kinase gene modified bone marrow mesenchymal stem cells as vehicles for antitumor therapy. Human Gene Therapy. https://www.liebertpub.com/doi/abs/10.1089/hum.2010.116?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=hum P. Gao. (2010) Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma. Cancer Letters. https://www.sciencedirect.com/science/article/abs/pii/S0304383509005710?via%3Dihub T. Muhammad. (2019) Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer. Stem Cell Research and Therapy. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1268-z B. Layek. (2018) Nano-engineered mesenchymal stem cells increase therapeutic efficacy of anticancer drug through true active tumor targeting. Molecular Cancer Therapeutics. https://mct.aacrjournals.org/content/17/6/1196.long Q. Hu. (2020) Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augements anti-leukaemia efficacy. Nature Biomedical Engineering. https://www.nature.com/articles/s41551-018-0310-2

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