One compartment in-vitro pharmacodynamic model.

Description

This model is used to simulate a patient’s elimination of the drug (t1/2) and the effects of antibiotic concentration and breakdown on antimicrobial activity and resistance development.

Acknowledgements

References

Blaser, J. U. R. G., Stone, B. B., Groner, M. C., & Zinner, S. H. (1987). Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance. Antimicrobial agents and chemotherapy, 31(7), 1054-1060.

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