Nutritional immunity with regards to zinc.

Description

Keratinocytes and the cells of the mucosal layers secreted large amounts of the S100A7 homodimer called psoriasin. Within the body cells release calprotectin which binds Zn2+ in addition to other divalent metals such as Mn2+, Fe2+ and Ni2+. Zn2+ is imported into the innate immune cells by the ZIP-family of transporters and then bound by metallothionein which also circulates in the blood along with calprotectin and psoriasin.

Acknowledgements

References

Murdoch, C. C.; Skaar, E. P. Nutritional Immunity: The Battle for Nutrient Metals at the Host–Pathogen Interface. Nature Reviews Microbiology 2022, 20 (11), 657–670. https://doi.org/10.1038/s41579-022-00745-6. Hood, M. I.; Skaar, E. P. Nutritional Immunity: Transition Metals at the Pathogen-Host Interface. Nature reviews. Microbiology 2012, 10 (8), 525–537.

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