Nucleic acid sensing in ANCA-associated vasculitis
Description
Activation and subsequent extravasation of neutrophils and the release DNA in the extracellular space can induce an immune reaction where DNA:antibody - immune complexes can be translocated/uptaken by monocyte-derived macrophages. Nucleic acid sensors like cGAS, were shown to sense this DNA and trigger an immune response by producing pathogenic type-I. Interferon (IFN). This in turn, was shown to damage the endothelial cell barrier and to induce pulmonary hemorrhages.
Acknowledgements
References
Nina Kessler & Susanne F. Viehmann, et al.; Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. J Exp Med 3 October 2022; 219 (10): e20220759. doi: https://doi.org/10.1084/jem.20220759
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