NMDAR-dependent Long-term Potentiation (LTP)

Description

N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) has been observed in many different brain regions and is dependent on postsynaptic NMDAR activation and calcium/calmodulin-dependent protein-kinase II (CaMKII) for its initiation. The voltage-dependent relief of the magnesium block of the NMDAR channel allows the synapse to detect coincident presynaptic release of glutamate (Glu) and postsynaptic depolarization. A-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) insertion into the postsynaptic membrane is a major mechanism underlying LTP activation.

Acknowledgements

References

Kauer, J. A., & Malenka, R. C. (2007). Synaptic plasticity and addiction. Nature Reviews Neuroscience, 8(11), 844–858. https://doi.org/10.1038/nrn2234

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