NMDAR-dependent Long-term Depression (LTD)
Description
This illustration describes the mechanism of triggering NMDAR-dependent long-term depression (LTD). It is triggered by Ca2+ entry through postsynaptic NMDAR channels, leading to increases in the activity of the protein phosphatases calcineurin and protein phosphatase 1 (PP1). The primary expression mechanism involves internalization of postsynaptic AMPARs.
Acknowledgements
References
Kauer, J. A., & Malenka, R. C. (2007). Synaptic plasticity and addiction. Nature Reviews Neuroscience, 8(11), 844–858. https://doi.org/10.1038/nrn2234
Hyun, J. S., Inoue, T., & Hayashi-Takagi, A. (2020). Multi-scale understanding of nmda receptor function in schizophrenia. Biomolecules, 10(8), 1172. https://doi.org/10.3390/biom10081172
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