Make scientific figures in minutes

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. When pathogens enter a wound, macrophages release cytokines, chemokines, and lipid mediators to relay chemical signals to leukocytes, like neutrophils. These neutrophils bind to specific receptors found on endothelial cells and adhere to them. Mast cells also bind to pathogens and release mediators to increase vascular permeability. The endothelial cells become more permeable to allow neutrophils to squeeze through into the infection site, a process known as extravasation. Finally, neutrophils engage in phagocytosis to eliminate the foreign matter.