Neutrophil Extracellular Traps: How HIV Protects the Pre-eclamptic Placenta
Description
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In pre-eclamptic placentae, syncytiotrophoblast microparticles (STBM) triggers the release of neutrophil extracellular traps (NETs). Subsequent neutrophil migration and degranulation lead to placental apoptosis and elevated STBM release. In HIV co-infected placentae, the HIV viral evasion mechanism triggers the release of interleukin-10 by the pre-eclamptic decidual reservoir of dendritic cells. This suppresses NETs and prevents placental apoptosis.
Acknowledgements
References
Moodley, M., Moodley, J., & Naicker, T. (2020). Neutrophil extracellular traps: The synergy source in the placentae of HIV infected women with pre-eclampsia. Pregnancy hypertension, 20, 69-74.
https://doi.org/10.1016/j.preghy.2020.03.007
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