Neurovascular Unit of the Mammalian Brain 5 x 5 in
Description
The neurovascular unit includes the five main cell types that form and interact with the blood-brain barrier (BBB) in the mammalian brain. Endothelial cells line the brain capillary walls and are connected by specialized tight junctions that limit the passage of many kinds of molecules. Pericytes work with the endothelial cells to promote blood-brain barrier formation. Astrocytes promote barrier maturation later in development, in addition to supporting the function of neurons and microglia.
Acknowledgements
References
K. S. Saili, et al., Blood-brain barrier development: Systems modeling and predictive toxicology. Birth Defects Research 109, 1680–1710 (2017).
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