Nanosystem for Death‑induced Gene Therapy in Cancer
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
The nanosystem are composed of polymer coated gold nanoparticles functionalized with molecules for the recognition of receptors of tumor cells. The binding between the nanosystem and the receptors of tumor cells induces specific endocytosis. After that, ligand-mediated endocytosis takes place. Finally, plasmid DNA enters the nucleus, and DNA is transcribed into mRNA and in the ribosomes translate it into a protein that induces cell death by different cellular pathways, for example apoptosis.
Acknowledgements
References
Jorge A. Roacho‑Perez. (2018) Nanoparticles for death‑induced gene therapy in cancer (Review). Spandidos publications. https://pubmed.ncbi.nlm.nih.gov/29257213/
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