Mutation of HOPS Complex Subunits
Description
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HOPS is a multisubunit homotypic fusion and protein sorting tethering complex which plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. When the VPS16 and the VPS41 subunits of the HOPS complex are mutated, we observe impaired endosome-lysosome and autophagosome-lysosome fusions.
Acknowledgements
References
Brocker et al.,. (2012) Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex. PNAS. https://doi.org/10.1073/pnas.1117797109
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