mTOR Signaling Pathway
Description
The mTOR signaling pathway is an intricate signaling network activated by insulin, growth factors, and other cues that plays a central role in various biological processes. It controls cell growth, proliferation, survival, and cytoskeletal organization in response to environmental cues.
It consists of two distinct complexes, mTORC1, and mTORC2, which control different cellular processes: mTORC1 promotes protein synthesis and cell growth, while mTORC2 regulates cell survival and cytoskeletal organization. Dysregulation of mTOR signaling has been implicated in numerous diseases, including cancer, metabolic disorders, and neurodegenerative conditions, making it an attractive target for therapeutic interventions.
[Template description adapted from GPT3.5, 2023]
Acknowledgements
References
Kim, S. G., Buel, G. R., & Blenis, J. (2013). Nutrient regulation of the mTOR complex 1 signaling pathway. Molecules and cells, 35(6), 463-473.
https://doi.org/10.1007/s10059-013-0138-2
Chapuis et al (2010). Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies. Leukemia, 24(10), 1686-1699.
https://doi.org/10.1038/leu.2010.170
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