Molecular mechanism of peritoneal injury
Description
DPP4 played a key role in peritoneal fibrosis and dysfunction through promoting EMT, inflammation, and angiogenesis. Furthermore, sitagliptin and exendin-4 treatments markedly inhibited DPP4 levels, resulting in ameliorating peritoneal fibrosis and functional impairment to prevent PD failure.
Acknowledgements
References
Li, YC., Sung, PH., Yang, YH. et al. Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis. Commun Biol 4, 144 (2021).
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