Molecular basis of the Agr system.
Description
This scheme illustrates the Agr system of Staphylococcus aureus. When transcription of the operon occurs, AgrD undergoes cyclization by AgrB creating an intermediate that is translocated out of the cell where it undergoes a second proteolysis producing the maturation of AIP. AIP binds to the AgrC receptor producing its autophosphorylation. In this way, the AgrA protein is phosphorylated by the receptor and binds to the promoters, producing transcription of the operon again.
Acknowledgements
References
Tan L, Li S.R, Jiang B, Hu X.M and Li S. (2018) Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System. Frontiers in Microbiology, 9 (55).
Wang B and Muir T. W. (2016) Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chemical Biology, 23(2):214-224.
Jenul C and Horswill A. R. (2018) Regulation of Staphylococcus aureus Virulence. Microbiology Spectrum, 7 (2).
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