miRNA Biogenesis Pathways

Description

miRNA biogenesis can be divided into the canonical pathway and non-canonical pathways. Non-canonical pathways can be sub grouped into the Drosha-independent pathways (involving mirtrons and m7G-pre-miRNAs) and Dicer-independent pathway (involving shRNA). All pathways start in the nucleus and end in the cytoplasm with the formation of a functional miRISC complex.

Acknowledgements

References

O'Brien J, Hayder H, Zayed Y, Peng C. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Frontiers in endocrinology (Lausanne) 2018 Aug 3,;9:402. Datta N, Johnson C, Kao D, Gurnani P, Alexander C, Polytarchou C, et al. MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis. Pharmacological research 2023 Aug 1,;194:106870.

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