miR-17~92 suppresses cervical cancer progression by inhibiting cell cycle regulator Cdt2
Description
miR-17~92 suppresses mRNA of Cdt2 via miRNA induced silencing, leading to inhibition of Cdt2 protein production. Suppression of Cdt2 protein eventually leads to stabilization of a replication licensing factor Set8 causing S phase arrest in the cancerous cells. This in turn leads to inhibition of proliferation, invasion and migration abilities of the cervical cancer cells
Acknowledgements
References
Kiran, S., Dar, A., Singh, S. K., Lee, K. Y., & Dutta, A. (2018). The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers. Molecular cell, 72(5), 823-835.
Singh, G., Sharma, S. K., & Singh, S. K. (2022). miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells. BMC cancer, 22(1), 777.
Abbas, T., Shibata, E., Park, J., Jha, S., Karnani, N., & Dutta, A. (2010). CRL4Cdt2 regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Molecular cell, 40(1), 9-21.
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