Microfluidic Device for Electronic Discrimination of T cells by Activation State
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
A key component of host defense against infections (such as COVID-19) is the activation of cellular immunity, characterized by T cell responses. When naïve T cells are activated, they go through changes in physioelectric properties. This microfluidic chip uses dielectrophoretic forces to electronically detect and separate naïve and activated T cells. This point-of-care device is both a rapid diagnostic for infection and a therapeutic tool to enrich for immuno-reactive T cells.
Acknowledgements
References
Patrick Han. (2020) Continuous Label-free Electronic Discrimination of T cells by Activation State. https://pubs.acs.org/doi/10.1021/acsnano.0c03018
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