Membrane turnover - Retrograde Trafficking
Description
Intracellular trafficking plays a crucial role in neuronal development, maintenance, and neurodegeneration. Inside the cells, cargo trafficking occurs by vesicles, where some events play to determine its destination and its correct delivery to cell surface, trans-golgi-network recycling, or lysosome fusion to further degradation. Early endosomes show PtdIns(3)P and Rab5 markers. From endocytosis to maturation, endosomes lose Rab5 markers which are replaced by Rab7a and PtdIns(3,5)-bisphosphate.
Acknowledgements
References
Seaman MNJ. The retromer complex-endosomal protein recycling and beyond. J Cell Sci 2012. https://doi.org/10.1242/jcs.103440.
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
![example of using the icon library](https://cdn.prod.website-files.com/621e6f1effebfe03881da9bd/64c7c0fc322ef8c15744f235_ezgif.com-video-to-gif%20(1).gif)