Mechanism of Action of Selective Serotonin Reuptake Inhibitors
Description
As the name suggests, selective serotonin reuptake inhibitors (SSRIs) exert action by inhibiting the serotonin transporter at the presynaptic axon terminal. By inhibiting it, an increased amount of serotonin (5-hydroxytryptamine or 5-HT) remains in the synaptic cleft and can stimulate postsynaptic receptors for a more extended period.
Acknowledgements
References
Chu A, Wadhwa R. Selective Serotonin Reuptake Inhibitors. [Updated 2023 Feb 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554406/
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