Mechanism of action of polysaccharide vaccines versus glycoconjugate vaccines
Description
The carrier protein from glycoconjugate vaccines is processed by the PS-specific B cell and resulting peptides are presented to peptide-specific T-cells which can help for the production of both plasma cells and memory B cells (T-cells dependent response). Polysaccharides from virulent bacteria stimulate B cells by cross-linking the B-cell receptors and drive the differentiation in plasma cells with production of low affinity antibodies (T-cells independent response).
Acknowledgements
References
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Pollard, A. J., Perrett, K. P. & Beverley, P. C. Maintaining protection against
invasive bacteria with protein- polysaccharide conjugate vaccines. Nat. Rev.
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