Mechanism of action of P. gingivalis virulence factors for rheumatoid arthritis
Description
P. gingivalis invades by secreting gingipains, which shred and degrade different cell receptors and ECM components. This disrupts signaling pathways and promotes tissue damage. PPAD and human PAD then citrullinate the liberated peptides. These citrullinated peptide antigens are recognized by antigen-presenting cells, resulting in the generation of anti-citrullinated protein antibodies (ACPAs) by the B cells. These ACPAs are associated with an increased risk of RA.
Acknowledgements
10.3389/fcimb.2022.987683
References
Chow YC, Yam HC, Gunasekaran B, Lai WY, Wo WY, Agarwal T, Ong YY, Cheong SL, Tan SA. Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases. Front Cell Infect Microbiol. 2022 Sep 29;12:987683. doi: 10.3389/fcimb.2022.987683. PMID: 36250046; PMCID: PMC9559808.
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