μ-Opioid Receptor Agonist Mechanism
Description
The μ-Opioid Receptor binds Morphine, an opioid agonist. Following this is the activation of the G-protein and α-GTP dissociation. This subunit causes the inhibition of adenylate cyclase, leading to a decrease in cAMP levels. The down-regulation of Ca2+ channels and the up-regulation of K+ channels is also caused by the activation of the α-subunit. A charge imbalance then forms across the membrane.
Acknowledgements
References
NYSORA. Opioids. NYSORA. https://www.nysora.com/opioids/.
Pathan, H.; Williams, J. Basic Opioid Pharmacology: An Update. British Journal of Pain 2012, 6 (1), 11–16. https://doi.org/10.1177/2049463712438493.
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