Local Estrogen Synthesis in Ovarian Cancer

Description

In ovarian tumor cells active estrogens form from androgen precursors via the aromatase pathway and from precursors estrogens via the sulfatase pathway. For the uptake of sulfated precursors special carriers are needed. AKR, aldo-keto reductase; CYP, cytochrome P450; DHEA, dehydroepiandrosterone; DHEA-S, dehydroepiandrosterone sulfate; E1-S, estrone sulfate; HSD, hydroxysteroid dehydrogenase; STS, steroid sulfatase; SULT, sulfotransferase.

Acknowledgements

References

Rižner, T. L., & Romano, A. (2023). Targeting the formation of estrogens for treatment of hormone dependent diseases-current status. Frontiers in pharmacology, 14, 1155558. https://doi-org.nukweb.nuk.uni-lj.si/10.3389/fphar.2023.1155558 Samavat, H., & Kurzer, M. S. (2015). Estrogen metabolism and breast cancer. Cancer letters, 356(2 Pt A), 231–243. https://doi-org.nukweb.nuk.uni-lj.si/10.1016/j.canlet.2014.04.018

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