Life Cycle of Rab27: A Monomeric GTPase That Regulates Vesicular Trafficking
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Rab27 is a small monomeric GTPase that acts as a molecular switch, cycling from an inactive state (GDP-bound) to an active state (GTP-bound). Following expression, Rab27 is post-translationally lipidated by Rab GeranylGeranylTransferase. Auxiliary proteins, i.e. a guanine nucleotide exchange factor (GEF) and a GTPase activating protein (GAP), are required to transition between the two states. Only Rab27-GTP can anchor to vesicles and bind to effector proteins thus regulating membrane secretion.
Acknowledgements
References
Hutagalung, A. H. et al. (2011) Role of Rab GTPases in membrane traffic and cell physiology.. Physiological Reviews. https://pubmed.ncbi.nlm.nih.gov/21248164/
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
.gif)
