Leukocyte Extravasation - The Role of Glycans in Inflammation
Description
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The movement of white blood cells (WBC) from the circulatory system to a site of inflammation is known as leukocyte extravasation. Released immune chemokines initiate expression of selectins on endothelial surfaces which have high affinity for Sialyl Lewis X glycan epitopes. This interaction facilitates endothelial adhesion and leukocyte movement towards the site of inflammation. For lymphocytes (a subtype of WBC), the selectin and glycan are found on opposite surfaces for the same interaction.
Acknowledgements
References
Taylor, M & Drickamer, K. (2019) Mammalian sugar-binding receptors: known functions and unexplored roles.. The FEBS Journal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563452/
Ley, K et. al.. (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nature Reviews Immunology. https://www.nature.com/articles/nri2156
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