Leptin Stimulates Synaptogenesis in Hippocampal Neurons via KLF4 and SOCS3
Description
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In developing hippocampal neurons, leptin induces maturation of spines, main sites of excitatory synapses. In non-treated neurons, high levels of signal transducer and activator of transcription 3 (STAT3) negatively regulates synapse formation causing less mature spines and excitatory postsynaptic currents. Leptin addition increases expression of Kruppel-Like Factor 4 (KLF4) and suppressor of cytokine signaling 3 (SOCS3), which inhibit STAT3, resulting in enhancement of glutamatergic synapses.
Acknowledgements
References
Dhar, M.. (2014) Leptin-induced spine formation requires TrpC channels and the CaM kinase cascade in the hippocampus. J. Neuroscience. https://www.jneurosci.org/content/34/30/10022
Sahin, GS. (2020) Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling. Molecular and Cellular Neuroscience. https://doi.org/10.1016/j.mcn.2020.103500
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