L-PGDS association with β cell proliferation
Description
L-PGDS helps in the production of PGD2 which leads to PPARγ activation and adiponectin release. Adiponectin binds to Adipo R1/2, which stimulates ceramidase activity to produce sphingosine from ceramide. This sphingosine then converts to S1P and binds with S1P receptor. Downstream AMPK gets activated, which directly inhibits NFκB, leads to inhibition of β-cell apoptosis, and increases proliferation. Also, the binding of S1P to S1P-receptor increases the phosphorylation of AKT.
Acknowledgements
References
Yanai, H., & Yoshida, H. (2019). Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives. International Journal of Molecular Sciences, 20(5), 1190. https://doi.org/10.3390/ijms20051190
Tao, C., Sifuentes, A., & Holland, W. L. (2014). Regulation of glucose and lipid homeostasis by adiponectin: Effects on hepatocytes, pancreatic β cells and adipocytes. Best Practice & Research Clinical Endocrinology & Metabolism, 28(1), 43-58. https://doi.org/10.1016/j.beem.2013.11.003
Fayyaz, S., Japtok, L., & Kleuser, B. (2014). Divergent Role of Sphingosine 1-Phosphate on Insulin Resistance. Cellular Physiology and Biochemistry, 34(1), 134-147. https://doi.org/10.1159/000362990
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