KRAS Signaling
Description
RAS functions as a critical molecular switch to regulate cellular signaling pathways involved in growth, proliferation, development, differentiation and survival. Normally, RAS proteins reside in the GDP-bound or inactive state. Following mitogenic stimulation by growth factors, GEFs are recruited to the plasma membrane. Binding of GEFs to RAS results in destabilization in nucleotide binding leading to the release of GDP from RAS and creation of a transient nucleotide free state.
Acknowledgements
References
https://doi.org/10.1016/j.celrep.2022.110322
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures