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An editable high resolution scientific image depicting KRAS Signaling

KRAS Signaling

Description

RAS functions as a critical molecular switch to regulate cellular signaling pathways involved in growth, proliferation, development, differentiation and survival. Normally, RAS proteins reside in the GDP-bound or inactive state. Following mitogenic stimulation by growth factors, GEFs are recruited to the plasma membrane. Binding of GEFs to RAS results in destabilization in nucleotide binding leading to the release of GDP from RAS and creation of a transient nucleotide free state.

Acknowledgements

References

https://doi.org/10.1016/j.celrep.2022.110322
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