Ketegenesis and ketolysis pathways in hepatic mitochondria.

Description

Ketogenesis primarily takes place in the mitochondria of the liver, using acetyl-CoA. Afterwards, extrahepatic tissues take up these ketone bodies, such as β-hydroxybutyrate (BHB) and acetoacetate (AcAc), via monocarboxylic acid transporters (MCT). In the mitochondria, a process known as ketolysis takes place in which BHB and AcAc are converted back into acetyl-CoA. During this conversion, ATP is generated via the tricarboxylic acid cycle (TCA) and the electron transport chain (ETC).

Acknowledgements

References

Hwang, C. Y., Choe, W., Yoon, K.-S., Ha, J., Kim, S. S., Yeo, E.-J., & Kang, I. (2022). Molecu-lar Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Po-tential in Cancer. Nutrients, 14(22), 4932. https://doi.org/10.3390/nu14224932

Get started with this template for free

Don’t start from scratch.

Create professional scientific illustrations quickly and easily, even without any design expertise

Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
Create figures that effectively communicate your research in half the time using our editable icons.
Use our PDB tool to quickly generate and customize protein structures

Get started now