Keap1–Nrf2 Pathway
Description
The Keap1-Nrf2 pathway is a signaling pathway involved in cellular responses to oxidative stress. The regulatory protein Keap1 regulates the activity of the transcription factor Nrf2. Under conditions of oxidative stress, Nrf2 is released from Keap1 and translocates to the nucleus, where it activates the expression of genes encoding antioxidant enzymes This pathway plays an important role in cell defense against oxidative damage and redox maintenance of homeostasis.
[Template description adapted from GPT3.5, 2023]
Acknowledgements
References
https://pubmed.ncbi.nlm.nih.gov/21365312/
https://www.caymanchem.com/news/nrf2-antioxidant-stress-response
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