Iron and Stress erythropoiesis

Description

During stress erythropoiesis, erythroblasts secrete erythroferrone (ERFE), which in turn blocks bone morphogenetic protein 6 (BMP6) in liver.The protein BMP 6 plays a role in hepcidin synthesis pathway results in reduced production of hepcidin.This leads to increased iron mobilization towards bone marrow for erythropoiesis.Transferrin (transports iron) levels marked by total iron binding capacity (TIBC) and erythropoietin levels escalated due to increased demand for erythroid synthesis.

Acknowledgements

References

Arezes J, Foy N, McHugh K, Sawant A, Quinkert D, Terraube V, Brinth A, Tam M, LaVallie ER, Taylor S, Armitage AE, Pasricha SR, Cunningham O, Lambert M, Draper SJ, Jasuja R, Drakesmith H. Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018 Oct 4;132(14):1473-1477. doi: 10.1182/blood-2018-06-857995. Epub 2018 Aug 10. PMID: 30097509; PMCID: PMC6238155

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