Intrinsic and Molecular Subtypes of Breast Cancer

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Breast cancer subtypes can be categorized based on their expression of hormone receptors (estrogen receptor (ER) and progesterone receptor (PR)), the proliferation marker Ki-67, and the receptor tyrosine kinase HER2. Targeted therapies, such as Herceptin (aimed at the HER2 protein) and Tamoxifen (aimed at the ER), can be used in the treatment of certain breast cancer subtypes. Prognosis varies based on the subtype of breast cancer.

Acknowledgements

References

Xiaofeng Dai et. al. (2015) Breast cancer intrinsic subtype classification, clinical use and future trends. Am J Cancer Res.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656721/ Paola De Cicco et. al. (2019) Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence. Nutrients. https://pubmed.ncbi.nlm.nih.gov/31277273/ Martin J. Larsen et. al. (2013) Classifications within Molecular Subtypes Enables Identification of BRCA1/BRCA2 Mutation Carriers by RNA Tumor Profiling. PLoS One. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660328/ Atif Ali Hashmi et. al. (2019) Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters. BMC Res Notes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755684/

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