Intestinal Infection Triggers Parkinson’s Disease-like Symptoms in Pink1−/− Mice
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
This figure summarizes the mechanisms behind an intestinal infection triggering Parkinson's disease-like symptoms in Pink1-/- mice. The loss of Pink1 results in the activation of CD8+ T cells in the periphery and in the brain following intestinal infection, which results in the killing of dopaminergic neurons in the substantia nigra.
Acknowledgements
References
Matheoud, D., Cannon, T., Voisin, A., Penttinen, A.M., Ramet, L., Fahmy, A. M., Ducrot, C., Laplante, A., Bourque, M.-J., Zhu, L., Cayrol, R., Campion, A. L., McBride, H. M., Gruenheid, S., Trudeau, L.-E., & Desjardins, M. (2019). Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice. Nature, 571(7766), 565–569. https://doi.org/10.1038/s41586-019-1405-y
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